Treatment and Prevention of Diaper Candida Discussion



Treatment and Prevention of Diaper Candida Discussion

QUESTION
Ms. Jones brings 6-week-old Sam to the clinic because of a bright red rash in the diaper area that has gotten worse since she started putting over-the-counter antibiotic cream on it 3 days ago. Sam is diagnosed with diaper Candida or a yeast infection. Clotrimazole (Lotrimin) topical TID for 14 days to the diaper area has been prescribed.

1. Briefly describe the therapeutic actions of Clotrimazole (Lotrimin).
2. Describe antifungal drugs uses and side effects.
3. Develop a teaching plan for Ms. Jones including age-appropriate considerations for Sam.
Treatment and Prevention of Diaper Candida Discussion

ANSWER
Treatment and Prevention of Diaper Candida Discussion

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Therapeutic Actions
The therapeutic actions of Clotrimazole entail damaging the permeability barrier in the cytoplasmic membrane of fungi (Campbell, 2019). As a result, Clotrimazole inhibits the biosynthesis of ergosterol by inhibiting the demethylation of 14 alpha lanosterol. These actions render fungal cells unable to construct functional cell membranes (Vitale, 2021). Besides, Clotrimazole promotes the growth of fungal cells in a hormone-like fashion. Effectively, the damage to the cell membrane kills the fungi cells causing skin infections as it makes their cellular content leak (Fölster‐Holst, 2018). The outcome is a decrease in symptoms of fungal infection.
Antifungal Drug Uses and Side Effects
Clotrimazole is used to treat an array of fungal skin infections. These include athlete’s foot, ringworm, infected nappy rash, rash in folds of skin (intertrigo), oral thrush, tinea corporis, jock itch, and yeast infections (Vitale, 2021). Some individuals may have side effects when using Clotrimazole. According to Alonso-Alonso et al., (2021) may include swelling in the area where the drug is used, irritation where the drug is used, burning, and development of blisters or sores that may ooze, drain, or crust over. Also, the drug may trigger allergic reactions such as peeling of the skin, swelling of the mouth, face, tongue, lips, or throat, wheezing, and trouble breathing, swallowing, or talking (Campbell, 2019).
Teaching Plan
Clotrimazole should be used for at least 2 weeks even if the signs of infections have disappeared (Sharifi-Heris et al., 2018). This will prevent the infection from coming back. Also, Clotrimazole needs to be applied to the affected area at least twice a day. Crucially, one has to wash their hand before using Clotrimazole then clean and dry the affected area before applying a small amount of the cream (Zhang & Michniak-Kohn, 2018).

References
Alonso-Alonso, C., Larburu-Aristizabal, I., Iglesias-Gaspar, M. T., Urreta-Barallobre, I., & Emparanza-Knorr, J. I. (2021). Incidence and factors associated with Candida infection in neonatal diaper dermatitis. Journal of Neonatal Nursing.
Campbell, J. R. (2019). Candida infections in children. Literature review current through: Feb.
Fölster‐Holst, R. (2018). Differential diagnoses of diaper dermatitis. Pediatric Dermatology, 35, s10-s18.
Sharifi-Heris, Z., Amiri Farahani, L., & Hasanpoor-Azghadi, S. B. (2018). A review study of diaper rash dermatitis treatments. Journal of Client-Centered Nursing Care, 4(1), 1-12.
Vitale, R. G. (2021). Role of Antifungal Combinations in difficult to treat Candida infections. Journal of Fungi, 7(9), 731.
Zhang, J., & Michniak-Kohn, B. B. (2018). Investigation of microemulsion and microemulsion gel formulations for dermal delivery of clotrimazole. International journal of pharmaceutics, 536(1), 345-352.

Treatment and Prevention of Diaper Candida Discussion


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