Pharmacokinetics and Pharmacodynamics



Pharmacokinetics and Pharmacodynamics

QUESTION
Part 1

Choose a drug that is used for the GI system(Protonix or generic Pantoprozole). Write a legal prescription for the drug for a fictitious patient. You are the provider. Be sure your prescription includes all legally correct patient information, provider information, medication information as well as any special instructions to the pharmacist. Your writing Assignment should include all the legal elements of a prescription.

Part 2

Write a 250-300 word paper to describe the pharmacokinetics and pharmacodynamics of the drug as well as specific patient education about the chosen drug. Reference your work using correct APA formatting. Utilize correct professional writing including grammar, punctuation, and mechanics.Directions
Pharmacokinetics and Pharmacodynamics

ANSWER
Pharmacokinetics and Pharmacodynamics

Student’s Name
Institutional Affiliation
Course Name and Number
Instructor’s Name
Date

Pharmacokinetics and Pharmacodynamics
Part 1

Part 2
Pantoprazole is a proton pump inhibitor used in treating conditions associated with gastric acid hypersecretion. Some include gastroesophageal reflux diseases and Zollinger Ellison syndrome (Krag et al., 2018).
Pharmacokinetics
Absorption
Following oral administration, peak plasma concentration is achieved after 2.5 hours. It undergoes first-pass metabolism, with a bioavailability of 77%. Absorption is not affected by the administration of antacids. However, administration with food delays its absorption (Ochoa et al., 2020).
Distribution
The volume of distribution of pantoprazole is estimated at 11 to 23.6L, with major distribution in the extracellular fluid. It is primarily bound to albumin, with a serum protein binding of 98% (Ochoa et al., 2020).
Metabolism
It is metabolized extensively in the liver by the cytochrome CYP 450 system. The metabolism does not depend on the route of administration. The metabolic pathways involved include methylation, sulfation, and oxidation. There is no evidence of the pharmacologic activity of the resulting metabolites (Ochoa et al., 2020).
Excretion
Elimination mainly occurs through urine, with approximately 71%, while 18% is excreted in feces through biliary excretion. However, there is no renal excretion of non-metabolized pantoprazole (Ochoa et al., 2020).

Pharmacodynamics
Pantoprazole is a proton pump inhibitor that covalently binds to the (H+, K+)-ATPase enzyme system, thereby inhibiting the final step of gastric acid production. This, therefore, results in inhibition of gastric acid secretion, regardless of the stimulus (Xiang et al., 2020).
Patient Education
o Do not take the drug longer than the duration prescribed.
o Use with care if you have a history of brittle bones, smoking, or alcohol intake.
o Call or see your doctor in case the adverse effects are prolonged.

References
Krag, M., Marker, S., Perner, A., Wetterslev, J., Wise, M. P., Schefold, J. C., … & Møller, M. H. (2018). Pantoprazole in patients at risk for gastrointestinal bleeding in the I.C.U. New England Journal of Medicine, 379(23), 2199-2208. https://www.nejm.org/doi/full/10.1056/nejmoa1714919
Ochoa, D., Román, M., Cabaleiro, T., Saiz-Rodríguez, M., Mejía, G., & Abad-Santos, F. (2020). Effect of food on the pharmacokinetics of omeprazole, pantoprazole and rabeprazole. BMC Pharmacology and Toxicology, 21(1), 1-9. https://bmcpharmacoltoxicol.biomedcentral.com/articles/10.1186/s40360-020-00433-2
XIANG, R., S.U.N., F., XIONG, L., YU, M., DAI, Q., & CHEN, Y. (2020). Pharmacokinetics and pharmacodynamics of (S)-pantoprazole sodium enteric-coated tablets in healthy subjects. Chinese Journal of Clinical Pharmacology and Therapeutics, 25(8), 903. http://manu41.magtech.com.cn/Jweb_clyl/EN/10.12092/j.issn.1009-2501.2020.08.009

Pharmacokinetics and Pharmacodynamics


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